CD84 / SLAMF5 Molecule
CD84 / SLAMF5 Molecule Synonym Name
CD84 / SLAMF5 Protein Products
|Cat No||Species||Product Description|
|CD4-H5229||Human||Human CD84 / SLAMF5 Protein|
CD84 / SLAMF5 Molecule Background
Leukocyte differentiation antigen CD84 is also known as SLAM family member 5 (SLAMF5), which belongs to immunoglobulin (Ig) superfamily. CD84 / SLAMF5 contains one Ig-like C2-type (immunoglobulin-like) domain. CD84 plays a role as adhesion receptor functioning by homophilic interactions and by clustering. CD84 / SLAMF5 increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway.
- (1) Martin M., et al., 2001, J. Immunol. 167:3668-3676.
- (2) Tangye S.G., et al., 2002, Eur. J. Immunol. 32:1640-1649.
- (3) Zaiss M., et al., 2003, Exp. Hematol. 31:798-805.