ACVR1B / ALK4 Molecule
ACVR1B Molecule Synonym Name
ACVR1B Protein Products
|Cat No||Species||Product Description|
|ACB-H5251||Human||Human Activin RIB / ACVR1B Protein, Fc Tag|
ACVR1B Molecule Background
Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.
- (1) Carcamo J., et al., 1994, Mol. Cell. Biol. 14:3810-3821.
- (2) Suzuki K., et al., 2010, Biochem. Biophys. Res. Commun. 394:639-645.
- (3) Harrison C.A., et al., 2003, J. Biol. Chem. 278:21129-21135.