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Browse By Molecule Name --->ACVR1B / ALK4 Molecule

ACVR1B / ALK4 Molecule  


ACVR1B Molecule Synonym Name

ACVR1b,ALK4,ACVRLK4,ACTR-IB,SKR2

ACVR1B Protein Products

Cat No Species Product Description
ACB-H5251HumanHuman Activin RIB / ACVR1B Protein, Fc Tag

ACVR1B Molecule Background

Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.

Reference

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