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TNFSF18 Molecule  


GITR Ligand Molecule Synonym Name

TNFSF18,AITRL,TL6,hGITRL,GITR Ligand

GITR Ligand Protein Products

Cat No Species Product Description
GIL-H526aHumanHuman GITR Ligand / TNFSF18 Protein, Fc Tag
GIL-M526xMouseMouse GITR Ligand / TNFSF18 Protein, Fc Tag

GITR Ligand Molecule Background

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.

Reference

  • (1) Tuyaerts S., et al., 2007, J. Leukoc. Biol. 82:93-105.
  • (2) Chattopadhyay K., et al., 2007, Proc. Natl. Acad. Sci. U.S.A. 104:19452-19457.

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