GITR Ligand Molecule Synonym Name
GITR Ligand Protein Products
|Cat No||Species||Product Description|
|GIL-H526a||Human||Human GITR Ligand / TNFSF18 Protein, Fc Tag|
|GIL-M526x||Mouse||Mouse GITR Ligand / TNFSF18 Protein, Fc Tag|
GITR Ligand Molecule Background
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.
- (1) Tuyaerts S., et al., 2007, J. Leukoc. Biol. 82:93-105.
- (2) Chattopadhyay K., et al., 2007, Proc. Natl. Acad. Sci. U.S.A. 104:19452-19457.