TNFRSF21 / DR6 Molecule
TNFRSF21 / DR6 Molecule Synonym Name
TNFRSF21, DR6, CD358, BM-018
TNFRSF21 / DR6 Protein Products
|Cat No||Species||Product Description|
|TN1-H5252||Human||Human TNFRSF21 /DR6 /CD358 Protein, With C-Fc Tag|
|TN1-H5223||Human||Human TNFRSF21 /DR6 /CD358 Protein|
TNFRSF21 / DR6 Molecule Background
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) is also known as death receptor 6 (DR6), which is a member of the TNF-receptor superfamily. TNFRSF21 contains one death domain and four TNFR-Cys repeats. TNFRSF21 / DR6 has been shown to activate NF-κB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors.
- (1) Pan G., et al., 1998, FEBS Lett. 431 (3): 351–356.
- (2) Kuester M., et al., 2011, J. Mol. Biol. 409 (2): 189–201.