SLAMF7 / CD319 Molecule
SLAMF7 / CD319 Molecule Synonym Name
SLAMF7 / CD319 Protein Products
|Cat No||Species||Product Description|
|SL7-H5225||Human||Human SLAMF7 / CRACC / CD319 Protein|
|SL7-H5256||Human||Human SLAMF7 / CRACC / CD319 Protein, Fc Tag|
SLAMF7 / CD319 Molecule Background
SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.
- (1) Bouchon A., et al., 2001, J. Immunol. 167:5517-5521.
- (2) Murphy J.J., et al., 2002, Biochem. J. 361:431-436.