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VSIG4 / Z39IG Molecule  


VSIG4 Molecule Synonym Name

VSIG4,CRIg,Z39IG

VSIG4 Protein Products

Cat No Species Product Description
VS4-H5226HumanHuman VSIG4 Protein

VSIG4 Molecule Background

V-set and immunoglobulin domain-containing protein 4 (VSIG4) is also known as Protein Z39Ig, is a type I transmembrane glycoprotein. VSIG4 is a B7 family-related protein and an Ig superfamily member. VSIG4 contains two Ig-like (immunoglobulin-like) domains. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production.

Reference

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