VSIG4 / Z39IG Molecule
VSIG4 Molecule Synonym Name
VSIG4 Protein Products
|Cat No||Species||Product Description|
|VS4-H5226||Human||Human VSIG4 Protein|
VSIG4 Molecule Background
V-set and immunoglobulin domain-containing protein 4 (VSIG4) is also known as Protein Z39Ig, is a type I transmembrane glycoprotein. VSIG4 is a B7 family-related protein and an Ig superfamily member. VSIG4 contains two Ig-like (immunoglobulin-like) domains. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production.
- (1) Vogt L., et al., 2006, J. Clin. Invest. 116:2817-2826.
- (2) Wiesmann C., et al., 2006, Nature 444:217-220.