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Browse By Molecule Name --->ROR1 / NTRKR1 Molecule

ROR1 / NTRKR1 Molecule  


ROR1 Molecule Synonym Name

ROR1,NTRKR1

ROR1 Protein Products

Cat No Species Product Description
RO1-H5221HumanHuman ROR1 (39-151, Ig-like domain) Protein
RO1-H5222HumanHuman ROR1 (165-305, Frizzled domain) Protein
RO1-H5223HumanHuman ROR1 (308-395, Kringle domain) Protein
RO1-H522yHumanHuman ROR1 Protein
RO1-H5250HumanHuman ROR1 Protein, Fc Tag
RO1-H82F4HumanBiotinylated Human ROR1 Protein, Fc Tag, Avi Tag (Avitag?)
RO1-M5221MouseMouse ROR1 Protein
RO1-M5250MouseMouse ROR1 Protein, Fc Tag
RO1-R5221RatRat ROR1 Protein

ROR1 Molecule Background

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

Reference

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