ROR1 / NTRKR1 Molecule
ROR1 Molecule Synonym Name
ROR1 Protein Products
|Cat No||Species||Product Description|
|RO1-H5221||Human||Human ROR1 (39-151, Ig-like domain) Protein|
|RO1-H5222||Human||Human ROR1 (165-305, Frizzled domain) Protein|
|RO1-H5223||Human||Human ROR1 (308-395, Kringle domain) Protein|
|RO1-H522y||Human||Human ROR1 Protein|
|RO1-H5250||Human||Human ROR1 Protein, Fc Tag|
|RO1-H82F4||Human||Biotinylated Human ROR1 Protein, Fc Tag, Avi Tag (Avitag?)|
|RO1-M5221||Mouse||Mouse ROR1 Protein|
|RO1-M5250||Mouse||Mouse ROR1 Protein, Fc Tag|
|RO1-R5221||Rat||Rat ROR1 Protein|
ROR1 Molecule Background
Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
- (1) Masiakowski P., et al., 1992, J. Biol. Chem. 267:26181-26190.
- (2) Reddy U.R., et al., 1996, Oncogene 13:1555-1559.
- (3) Greenman C., et al., 2007, Nature 446:153-158.