Browse Products By Molecule:

This web search service is supported by Google Inc.

Browse By Molecule Name --->ANGPTL3 Molecule

ANGPTL3 Molecule  


ANGPTL3 Molecule Synonym Name

ANGPTL3,ANGPT5,ANG-5,Angiopoietin-5,FHBL2

ANGPTL3 Protein Products

Cat No Species Product Description
AN3-H5226HumanHuman Angiopoietin-like 3 / ANGPTL3 Protein

ANGPTL3 Molecule Background

Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.

Reference

Related Molecule