Myocilin Molecule Synonym Name
Myocilin Protein Products
|Cat No||Species||Product Description|
|MYC-H5222||Human||Human Myocilin / MYOC Protein|
Myocilin Molecule Background
Myocilin, trabecular meshwork inducible glucocorticoid response is also known as MYOC, GLC1A, GPOA, JOAG, JOAG1, TIGR. Myocilin / MYOC contains one olfactomedin-like domain. Myocilin is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.
- (1) Young H. Kwon., et al., 2009, N Engl J Med, 360:1113-24.
- (2) Torrado, Mario., et al., 2002, Hum. Mol. Genet. (England) 11 (11): 1291–301.