Kallikrein 8 Molecule Synonym Name
Kallikrein 8 Protein Products
|Cat No||Species||Product Description|
|KL8-H5229||Human||Human Kallikrein 8 / KLK-8 Protein|
Kallikrein 8 Molecule Background
Kallikrein-8 (KLK8) is also known as Neuropsin (NP or NRPN), Ovasin, Serine protease 19 (PRSS19), Tumor-associated differentially expressed gene 14 protein (TADG-14), which belongs to the peptidase S1 family and Kallikrein subfamily. KLK8 contains 1 peptidase S1 domain. KLK8 is pH dependence protein and the optimum pH is 8.5, and the protein is active from pH 7-10. KLK8 is expressed at high levels in serum, ascites fluid and tumor cytosol of advanced stage ovarian cancer patients and may serve as a marker of ovarian cancer. KLK8 cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys, and the catalytic activity of KLK8 is inhibited by a range of serine protease inhibitors including antipain, aprotinin, leupeptin, benzamidine and soybean trypsin inhibitor.
- (1) Rajapakse S., et al., 2005, FEBS Lett. 579:6879-6884.
- (2) Scott F.L., et al., 2007, J. Biochem. 142:435-442.
- (3) Brattsand M., et al., 2009, J. Invest. Dermatol. 129:1656-1665.