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KLK8 Molecule  


Kallikrein 8 Molecule Synonym Name

KLK8,Kallikrein-8,Neuropsin,Ovasin,NRPN,PRSS19,TADG14,NP,hK8

Kallikrein 8 Protein Products

Cat No Species Product Description
KL8-H5229HumanHuman Kallikrein 8 / KLK-8 Protein

Kallikrein 8 Molecule Background

Kallikrein-8 (KLK8) is also known as Neuropsin (NP or NRPN), Ovasin, Serine protease 19 (PRSS19), Tumor-associated differentially expressed gene 14 protein (TADG-14), which belongs to the peptidase S1 family and Kallikrein subfamily. KLK8 contains 1 peptidase S1 domain. KLK8 is pH dependence protein and the optimum pH is 8.5, and the protein is active from pH 7-10. KLK8 is expressed at high levels in serum, ascites fluid and tumor cytosol of advanced stage ovarian cancer patients and may serve as a marker of ovarian cancer. KLK8 cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys, and the catalytic activity of KLK8 is inhibited by a range of serine protease inhibitors including antipain, aprotinin, leupeptin, benzamidine and soybean trypsin inhibitor.

Reference

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