DcR3 Molecule Synonym Name
DcR3 Protein Products
|Cat No||Species||Product Description|
|TNB-H5255||Human||Human DcR3 / TNFRSF6B Protein, Fc Tag|
DcR3 Molecule Background
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.
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- (3) Zhang J., et al., 2001, J. Clin. Invest. 107 (11): 1459–68.