BCMA / TNFRSF17 Molecule Synonym Name
BCMA / TNFRSF17 Protein Products
|Cat No||Species||Product Description|
|BC7-H5254||Human||Human BCMA / TNFRSF17 Protein, Fc Tag|
|BC7-H82F0||Human||Biotinylated Human BCMA / TNFRSF17 Protein, Fc Tag, Avi Tag (Avitag™)|
|BCA-C82F4||Cynomolgus||Biotinylated Cynomolgus BCMA / TNFRSF17 Protein, Fc Tag, Avi Tag (Avitag™)|
|BCA-H522y||Human||Human BCMA / TNFRSF17 Protein|
|BCA-HF254||Human||FITC-Labeled Human BCMA / TNFRSF17 Protein, Fc Tag|
BCMA / TNFRSF17 Molecule Background
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
- (1) Hatzoglou A., et al., 2000, J. Immunol. 165:1322-1330.
- (2) Gross J.A., et al., 2000, Nature 404:995-999.
- (3) Yu G., et al., 2000, Nat. Immunol. 1:252-256.