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CD244 / 2B4 Molecule  

2B4 / CD244 Molecule Synonym Name


2B4 / CD244 Protein Products

Cat No Species Product Description
2B4-H5224 Human Human 2B4 / CD244 / SLAMF4 Protein
2B4-H5255 Human Human 2B4 / CD244 / SLAMF4 Protein, Fc Tag
2B4-H82F0 Human Biotinylated Human 2B4 / CD244 / SLAMF4 Protein, Fc Tag, Avi Tag (Avitag™)

2B4 / CD244 Molecule Background

Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.


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