CD244 / 2B4 Molecule
2B4 / CD244 Molecule Synonym Name
2B4 / CD244 Protein Products
|Cat No||Species||Product Description|
|2B4-H5224||Human||Human 2B4 / CD244 / SLAMF4 Protein|
|2B4-H5255||Human||Human 2B4 / CD244 / SLAMF4 Protein, Fc Tag|
|2B4-H82F0||Human||Biotinylated Human 2B4 / CD244 / SLAMF4 Protein, Fc Tag, Avi Tag (Avitag™)|
2B4 / CD244 Molecule Background
Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.
- (1) Nakajima H., et al., 1999, Eur. J. Immunol. 29:1676-1683.
- (2) Kubin M.Z., et al., 1999, Eur. J. Immunol. 29:3466-3477.
- (3) Boles K.S., et al., 1999, Tissue Antigens 54:27-34.