AXL / UFO Molecule
Axl Molecule Synonym Name
Axl Protein Products
|Cat No||Species||Product Description|
|AXL-H5226||Human||Human Axl Protein|
Axl Molecule Background
AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.
- (1) Varnum B.C., et al., 1995, Nature 373:623-626.
- (2) Gallicchio M., et al., 2005, Blood 105:1970-1976.
- (3) Park I.K., et al., 2009, Blood 113:2470-2477.