SFRP4 / FRPHE Molecule
SFRP4 / FRPHE Molecule Synonym Name
SFRP4, FRP-4, FRPHE
SFRP4 / FRPHE Protein Products
|Cat No||Species||Product Description|
|SF4-H5224||Human||Human sFRP4 Protein|
SFRP4 / FRPHE Molecule Background
Secreted frizzled-related protein 4 (sFRP-4) is also known as Frizzled protein, human endometrium (FRPHE), FRP-4, which belongs to the secreted frizzled-related protein (sFRP) family. sFRP-4 contains one FZ (frizzled) domain and one NTR domain. sFRP-4 is expressed in mesenchymal cells and highly expressed in the stroma of proliferative endometrium. sFRP4 may act as a regulator of adult uterine morphology and function. sFRP4 increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. sFRP4 has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
- (1) Berndt T., et al., 2003, J. Clin. Invest. 112:785-794.
- (2) Drake J., et al., 2009, Eur. J. Gynaecol. Oncol. 30:133-141.