ANGPTL4 Molecule Synonym Name
ANGPTL4,ANGPTL2,ARP4,FIAF,HFARP,NL2,PGAR,pp1158,Angiopoietin like 4
ANGPTL4 Protein Products
|Cat No||Species||Product Description|
|AN4-H5243||Human||Human Angiopoietin-like 4 / ANGPTL4 (166-406) Protein|
ANGPTL4 Molecule Background
Angiopoietin-related protein 4 (ANGPTL4) is also known as Hepatic fibrinogen / angiopoietin - related protein (HFARP), ARP4, PGAR. ANGPTL4 contains one fibrinogen C-terminal domain. ANGPTL4 is a homooligomer , and the homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix. ANGPTL4 may act as a regulator of angiogenesis and modulate tumorigenesis. ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action.
- (1) Yoon J.C., et al., 2000, Mol. Cell. Biol. 20:5343-5349.
- (2) Ito Y., et al., 2003, Cancer Res. 63:6651-6657.
- (3) Zhu H., et al., 2002, Zhonghua Zhong Liu Za Zhi 24:123-125.