Frizzled-5 / FZD5 Molecule Synonym Name
Frizzled-5 / FZD5 Protein Products
|Cat No||Species||Product Description|
|FZ5-H5259||Human||Human Frizzled-5 / FZD5 Protein, Fc Tag|
Frizzled-5 / FZD5 Molecule Background
Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.
- (1) Hsieh J.C., et al., 1999, Proc. Natl. Acad. Sci. U.S.A. 96:3546-3551.
- (2) Hao H.X., et al., 2012, Nature 485:195-200.