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FZD2 Molecule  


Frizzled-2 / FZD2 Molecule Synonym Name

FZD2,Frizzled-2,Fz-2,hFz2,FzE2

Frizzled-2 / FZD2 Protein Products

Cat No Species Product Description
FZ2-H5251HumanHuman Frizzled-2 / FZD2 Protein, Fc Tag

Frizzled-2 / FZD2 Molecule Background

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

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