ENPP-2 Molecule Synonym Name
ENPP-2 Protein Products
|Cat No||Species||Product Description|
|EN2-H5241||Human||Human ENPP-2 / Autotaxin Protein|
ENPP-2 Molecule Background
Autotaxin also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 (E-NPP 2 or ENPP2), Extracellular lysophospholipase D (LysoPLD), Autotaxin (ATX or ATX-X), which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP2 contains two SMB (somatomedin-B) domains. ENPP2 hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. ENPP2 can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. ENPP2 stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.
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- (2) Nam S.W., et al., 2001, Cancer Res. 61:6938-6944.
- (3) Hausmann J., et al., 2011, Nat. Struct. Mol. Biol. 18:198-204.