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Browse By Molecule Name --->B7H4 / VTCN1 Molecule

B7H4 / VTCN1 Molecule  


B7-H4 Molecule Synonym Name

B7-H4,VTCN1,B7S1,B7h.5

B7-H4 Protein Products

Cat No Species Product Description
B74-H5222HumanHuman B7-H4 Protein
B74-H8222HumanBiotinylated Human B7-H4, ultra sensitivity (primary amine labeling)
B74-H82E2HumanBiotinylated Human B7-H4 Protein (recommended for biopanning), Avi Tag (Avitag?)

B7-H4 Molecule Background

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

Reference

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