B7H4 / VTCN1 Molecule
B7-H4 Molecule Synonym Name
B7-H4 Protein Products
|Cat No||Species||Product Description|
|B74-H5222||Human||Human B7-H4 Protein|
|B74-H8222||Human||Biotinylated Human B7-H4, ultra sensitivity (primary amine labeling)|
|B74-H82E2||Human||Biotinylated Human B7-H4 Protein (recommended for biopanning), Avi Tag (Avitag?)|
B7-H4 Molecule Background
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
- (1) Salceda S., et al., 2005, Exp. Cell Res. 306:128-141.
- (2) Kryczek I., et al., 2006, J. Exp. Med. 203:871-881.
- (3) Miyatake T., et al., 2007, Gynecol. Oncol. 106:119-127.