TREM1 / CD354 Molecule
TREM1 / CD354 Molecule Synonym Name
TREM1 / CD354 Protein Products
|Cat No||Species||Product Description|
|TR1-H5220||Human||Human TREM1 /CD354 Protein|
|TR1-H5251||Human||Human TREM1 /CD354 Protein,With C-Fc Tag|
TREM1 / CD354 Molecule Background
Triggering receptor expressed on myeloid cells 1 (TREM1) is also known as CD antigen CD354, and is a type I transmembrane protein with a single Ig-like domain. TREM1 is highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. TREM-1 / CD354 stimulates neutrophil and monocyte-mediated inflammatory responses, and also triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. TREM1 can interacts with TYROBP / DAP12.
- (1) Bouchon A., et al., 2000, J. Immunol. 164:4991-4995.
- (2) Bouchon A., et al., 2001, Nature 410:1103-1107.
- (3) Kelker M.S., et al., 2004, J. Mol. Biol. 342:1237-1248.