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Browse By Molecule Name --->AGER / RAGE Molecule

AGER / RAGE Molecule  


RAGE / AGER Molecule Synonym Name

AGER,RAGE

RAGE / AGER Protein Products

Cat No Species Product Description
AGR-H5253HumanHuman RAGE / AGER Protein, Fc Tag

RAGE / AGER Molecule Background

Advanced glycosylation end product-specific receptor (AGER) is also known as RAGE, and is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. AGER is highly expressed in endothelial cells. AGER mediates interactions of advanced glycosylation end products (AGE), and also accumulates in vascular tissue in aging and at an accelerated rate in diabetes, as well as acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGER / RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.

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