Kininogen 1 Molecule Synonym Name
Kininogen 1 Protein Products
|Cat No||Species||Product Description|
|KN1-H5225||Human||Human Kininogen 1 / KNG1 (LMW) Protein|
Kininogen 1 Molecule Background
Kininogen-1 (KNG1) is also known as HMWK, BDK, KNG, is a secreted protein which contains three cystatin domains. KNG1 can be cleaved into the following six chains: Kininogen-1 heavy chain, T-kinin, Bradykinin, Lysyl-bradykinin, Kininogen-1 light chain, Low molecular weight growth-promoting factor. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes; LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
- (1) Kellermann J., et al., 1986, Eur. J. Biochem. 154:471-478.
- (2) Wunderer G., et al., 1990, Biol. Chem. Hoppe-Seyler 371:977-981.