CD22 / SIGLEC2 Molecule
Siglec-2 / CD22 Molecule Synonym Name
Siglec-2 / CD22 Protein Products
|Cat No||Species||Product Description|
|SI2-H5228||Human||Human Siglec-2 / CD22 (176-687) Protein|
Siglec-2 / CD22 Molecule Background
B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
- (1) Hatta Y., et al., 1999, Immunogenetics 49:280-286.
- (2) Doody G.M., et al., 1995, Science 269:242-244.
- (3) Tuscano J.M., et al., 1996, Eur. J. Immunol. 26:1246-1252.