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Browse By Molecule Name --->INSR / CD220 Molecule

INSR / CD220 Molecule  


Insulin R Molecule Synonym Name

INSR,Insulin receptor,IR,CD220

Insulin R Protein Products

Cat No Species Product Description
INR-H5229 Human Human Insulin R / CD220 (28-944) Protein

Insulin R Molecule Background

Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.

Reference

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