IL-18BP Molecule Synonym Name
IL-18BP Protein Products
|Cat No||Species||Product Description|
|ILP-H5222||Human||Human IL-18BP Protein|
|ILP-H5253||Human||Human IL-18BP Protein, Fc Tag|
IL-18BP Molecule Background
Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.
- (1) Novick D., et al., 1999, Immunity 10:127-136.
- (2) Aizawa Y., et al., 1999, FEBS Lett. 445:338-342.
- (3) Halim A., et al., 2011, Mol. Cell. Proteomics 0:0-0.