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IL18BP Molecule  


IL-18BP Molecule Synonym Name

IL18BP,IL18BPa,Tadekinig-alfa

IL-18BP Protein Products

Cat No Species Product Description
ILP-H5222HumanHuman IL-18BP Protein
ILP-H5253HumanHuman IL-18BP Protein, Fc Tag

IL-18BP Molecule Background

Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.

Reference

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