CFD / Adipsin Molecule
CFD Molecule Synonym Name
CFD,Adipsin,PFD,DF,Complement factor D
CFD Protein Products
|Cat No||Species||Product Description|
|CFD-H5227||Human||Human Complement Factor D / CFD Protein|
CFD Molecule Background
Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.
- (1) White R.T., et al., 1992, J. Biol. Chem. 267:9210-9213.
- (2) Johnson D.M.A., et al., 1984, FEBS Lett. 166:347-351.
- (3) Sprong T., et al., 2006, Blood 107:4865-4870.