Fumarase (FH) Molecule Synonym Name
Fumarase (FH) Protein Products
|Cat No||Species||Product Description|
|FUE-H5125||Human||Human Fumarase (FH) Protein|
Fumarase (FH) Molecule Background
Fumarate hydratase, mitochondrial is also known as Fumarase or FH, which belongs to the class-II fumarase/aspartase family and Fumarase subfamily. Fumarase is a homotetramer protein which is expressed in red blood cells. There are two substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. Fumarase also acts as a tumor suppressor.
- (1) Choudhary C., et al., 2009, Science 325:834-840.
- (2) von Lohneysen K., et al., 2012, PLoS ONE 7:E34237-E34237.
- (3) Tomlinson I.P.M., et al., 2002, Nat. Genet. 30:406-410.