SERPINE2 / GDN Molecule
Serpin E2 Molecule Synonym Name
SERPINE2,Glia-derived nexin,GDN,Peptidase inhibitor 7,PI-7,Protease nexin 1,PN-1,Serpin E2,SerpinE2,PI7
Serpin E2 Protein Products
|Cat No||Species||Product Description|
|SE2-H5225||Human||Human Serpin E2 / PN1 Protein|
Serpin E2 Molecule Background
SERPINE2 is also known as Glia-derived nexin (GDN), Peptidase inhibitor 7 (PI7), Protease nexin 1(PN1). SERPINE2 is a secreted glycoprotein which belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). PAI-1 / GDN is also implicated in adipose tissue development. It suggests that PAI-1 inhibitors serve in the control of atherothrombosis. Defects in Serpin E1 / PN1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma.
- (1) Gloor S.M., et al., 1986, Cell 47:687-693.
- (2) Scott R.W., et al., 1985, J. Biol. Chem. 260:7029-7034.