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IL6ST / gp130 Molecule  


IL-6 R beta / CD130 Molecule Synonym Name

IL6ST,gp130,CD130,IL-6RB,IL-6R-beta,CDw130

IL-6 R beta / CD130 Protein Products

Cat No Species Product Description
ILT-M5252MouseMouse gp130 / CD130 / IL-6 R beta Protein, Fc Tag
ILT-M52H1MouseMouse gp130 / CD130 / IL-6 R beta Protein

IL-6 R beta / CD130 Molecule Background

Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.

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