CD5 / LEU1 Molecule
CD5 Molecule Synonym Name
CD5 Protein Products
|Cat No||Species||Product Description|
|CD5-H52H5||Human||Human CD5 Protein|
CD5 Molecule Background
T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.
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- (3) Rodamilans B., et al., 2007, J. Biol. Chem. 282:12669-12677.