IFN-alpha / beta R2 Molecule Synonym Name
IFNAR2,IFNARB,IFNABR,IFN-R-2,IFN-alpha/beta receptor 2
IFN-alpha / beta R2 Protein Products
|Cat No||Species||Product Description|
|IF2-H5224||Human||Human IFN-alpha / beta R2 Protein|
|IF2-H5255||Human||Human IFN-alpha / beta R2 Protein, Fc Tag|
IFN-alpha / beta R2 Molecule Background
Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the?type II cytokine receptor family. IFNAR2 can associate with IFNAR1 to form the type I interferon receptor. IFNAR2 is a receptor for interferons alpha and beta.IFNAR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFNAR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFNAR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection.
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