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Your Position: Home > TIGIT / VSIG9 Molecule

TIGIT Molecule Synonym Name

TIGIT,VSIG9,VSTM3

TIGIT Protein Products

Cat No Species Product Description
TIT-C5223CynomolgusCynomolgus TIGIT Protein
TIT-C5254CynomolgusCynomolgus TIGIT Protein, Fc Tag
TIT-H5254HumanHuman TIGIT Protein, Fc Tag
TIT-H52H3HumanHuman TIGIT Protein
TIT-H82E5HumanBiotinylated Human TIGIT Protein, Avi Tag (Avitag?)
TIT-H82F1HumanBiotinylated Human TIGIT Protein, Fc Tag, Avi Tag (Avitag?)
TIT-M5257MouseMouse TIGIT Protein, Fc Tag
TIT-M52E6MouseMouse TIGIT Protein
TIT-R5258RatRat TIGIT Protein, Fc Tag
TIT-R5259RabbitRabbit TIGIT Protein, Fc Tag
TIT-H5253HumanHuman TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin

TIGIT Molecule Background

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Reference

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