TIGIT / VSIG9 Molecule
TIGIT Molecule Synonym Name
TIGIT Protein Products
|Cat No||Species||Product Description|
|TIT-C5223||Cynomolgus||Cynomolgus TIGIT Protein|
|TIT-C5254||Cynomolgus||Cynomolgus TIGIT Protein, Fc Tag|
|TIT-H5254||Human||Human TIGIT Protein, Fc Tag|
|TIT-H52H3||Human||Human TIGIT Protein|
|TIT-H82E5||Human||Biotinylated Human TIGIT Protein, Avi Tag (Avitag?)|
|TIT-H82F1||Human||Biotinylated Human TIGIT Protein, Fc Tag, Avi Tag (Avitag?)|
|TIT-M5257||Mouse||Mouse TIGIT Protein, Fc Tag|
|TIT-M52E6||Mouse||Mouse TIGIT Protein|
|TIT-R5258||Rat||Rat TIGIT Protein, Fc Tag|
|TIT-R5259||Rabbit||Rabbit TIGIT Protein, Fc Tag|
|TIT-H5253||Human||Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin|
TIGIT Molecule Background
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
- (1) Yu X., et al., 2009, Nat. Immunol. 10:48-57.
- (2) Stengel K.F., et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109:5399-5404.
- (3) Lozano E., et al., 2012, J. Immunol. 188:3869-3875.