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DDR2 / CD167b Molecule  


DDR2 Molecule Synonym Name

DDR2,CD167b,NTRKR3,TKT,TYRO10

DDR2 Protein Products

Cat No Species Product Description
DD2-C5256Rhesus macaqueRhesus macaque DDR2 Protein, Fc Tag
DD2-C52H5Rhesus macaqueRhesus macaque DDR2 Protein

DDR2 Molecule Background

Discoidin domain-containing receptor 2 (DDR2) is also known as CD167 antigen-like family member B (CD167b), Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3(NTRKR3), Tyrosine-protein kinase TYRO10, Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. DDR2 is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. DDR2 regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. DDR2 promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

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