LTBR / TNFRSF3 Molecule
LTBR / TNFRSF3 Molecule Synonym Name
LTBR / TNFRSF3 Protein Products
|Cat No||Species||Product Description|
|LTR-H5251||Human||Human LTBR / TNFRSF3 Protein, Fc Tag|
LTBR / TNFRSF3 Molecule Background
Lymphotoxin-beta receptor (LTBR) is also known as Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), Tumor necrosis factor receptor type III (TNF-RIII), which is a single-pass type I membrane protein containing four TNFR-Cys repeat regions. Except for interacting with HCV core protein, LTBR can not only associate with itself, but also can associate with TRAF3, TRAF4 and TRAF5. As the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT, LTBR promotes apoptosis via TRAF3 and TRAF5. Furthermore, LTBR may play a role in the development of lymphoid organs.
- (1) Rooney I.A., et al., 2000, J. Biol. Chem. 275:14307-14315.
- (2) Nakano H., et al., 1996, J. Biol. Chem. 271:14661-14664.
- (3) Krajewska M., et al., 1998, Am. J. Pathol. 152:1549-1561.