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LTBR

Brief Information

Name:Tumor necrosis factor receptor superfamily member 3
Target Synonym:Lymphotoxin-beta receptor,Tumor necrosis factor receptor type III,LTBR,Tumor necrosis factor receptor superfamily member 3,D12S370,TNFRSF3,TNFCR,TNFR3,TNFR Superfamily, Member 3,Lymphotoxin B Receptor,LT-BETA-R,TNF-R-III,TNFR2-RP,TNF-RIII,TNFR-III,TNFR-RP,Lymphotoxin beta Receptor,Tumor necrosis factor C receptor,Tumor Necrosis Factor Receptor 2-Related Protein,Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3)
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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Part of Bioactivity data

LTR-C52H3-ELISA
 LTBR ELISA

Immobilized Cynomolgus LTBR / TNFRSF3 Protein, His Tag (Cat. No. LTR-C52H3) at 5 μg/mL (100 μL/well) can bind Human LIGHT Protein, Mouse IgG2a Fc Tag (Cat. No. LIT-H5256) with a linear range of 0.2-3 ng/mL (QC tested).

LTR-H52E3-MALS-HPLC
LTBR MALS images

The purity of Human LTBR Protein, His,Avitag (Cat. No. LTR-H52E3) is more than 90% and the molecular weight of this protein is around 25-38 kDa verified by SEC-MALS.

Synonym Name

LTBR,D12S370,TNFCR,TNFR3,TNFRSF3,TNFRIII

Background

Lymphotoxin-beta receptor (LTBR) is also known as Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), Tumor necrosis factor receptor type III (TNF-RIII), which is a single-pass type I membrane protein containing four TNFR-Cys repeat regions. Except for interacting with HCV core protein, LTBR can not only associate with itself, but also can associate with TRAF3, TRAF4 and TRAF5. As the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT, LTBR promotes apoptosis via TRAF3 and TRAF5. Furthermore, LTBR may play a role in the development of lymphoid organs.

Clinical and Translational Updates

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