Fetuin B / FETUB Molecule Synonym Name
Fetuin B / FETUB Protein Products
|Cat No||Species||Product Description|
|FEB-H52H7||Human||Human Fetuin B / FETUA Protein|
Fetuin B / FETUB Molecule Background
Fetuin-B (FETUB), a second member of the fetuin family in mammals, is also known as Fetuin-like protein IRL685, 16G2 and Gugu, which is expressed in liver and testis and contains 2 cystatin fetuin-B-type domains. FETUB is a protease inhibitor required for egg fertilization. FETUB is also required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity). As a liver-derived plasma protein, FETUB is essential for fertilization.
- (1) Olivier E., et al., 2000, Biochem. J. 350:589-597.
- (2) Dietzel E., et al., 2013, Dev. Cell 25:106-112.
- (3) Muzny D.M., et al., 2006, Nature 440:1194-1198.