UCHL1 / PGP9.5 Molecule
UCH-L1 Molecule Synonym Name
UCH-L1 Protein Products
|Cat No||Species||Product Description|
|UC1-H5140||Human||Human UCH-L1 Protein|
UCH-L1 Molecule Background
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) ,a member of the peptidase C12 family, is also known as neuron cytoplasmic protein 9.5 (PGP 9.5) and ubiquitin thioesterase L1.About 30% of total UCHL1 is associated with membranes in brain. UCHL1 is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also,UCHL1 can bind to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity. Furthermore, the mutations of UCHL1 gene can result in parkinson disease 5.
- (1) Choi J., et al., 2004, J. Biol. Chem. 279:13256-13264.
- (2) Liu Y., et al., 2002, Cell 111:209-218.
- (3) Choudhary C., et al., 2009, Science 325:834-840.