S100A1 Molecule Synonym Name
S100A1 Protein Products
|Cat No||Species||Product Description|
|S11-H5124||Human||Human S100A1 Protein|
S100A1 Molecule Background
Protein S100-A1 / S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100-A1 can weakly bind calcium but bind zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
- (1) Engelkamp D., et al., 1992, Biochemistry 31:10258-10264.
- (2) Wang G., et al., 2004, Biochem. J. 382:375-383.
- (3) Yamaguchi F., 2012, J. Biol. Chem. 287:13787-13798.