UBE2H / UbcH2 Molecule
UbcH2 / UBE2H Molecule Synonym Name
UbcH2 / UBE2H Protein Products
|Cat No||Species||Product Description|
|UBH-H513x||Human||Human UbcH2 / UBE2H Protein, GST Tag|
UbcH2 / UBE2H Molecule Background
Ubiquitin-conjugating enzyme E2 H (UBE2H), a member of the ubiquitin-conjugating enzyme family, is also known as ubiquitin carrier protein H, ubiquitin-conjugating enzyme E2-20K and ubiquitin-protein ligase H. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. At the same time, ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. Furthermore,UBE2H can accept ubiquitin from the E1 complex and catalyze its covalent attachment to other proteins. In vitro,UBE2H can aslo catalyze 'Lys-11'- and 'Lys-48'-linked polyubiquitination, and it is capable, in vitro, to ubiquitinate histone H2A.
- (1) Kaiser P., et al., 1994, J. Biol. Chem. 269:8797-8802.
- (2) David Y., et al., 2010, J. Biol. Chem. 285:8595-8604.
- (3) Wefes I et al., 1995, Proc Natl Acad Sci U S A. 92(11):4982-6.