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FZD4 / CD344 Molecule  


Frizzled-4 / FZD4 Molecule Synonym Name

FZD4,Frizzled-4,CD344,Fz-4,hFz4,FzE4

Frizzled-4 / FZD4 Protein Products

Cat No Species Product Description
FZ4-H5250HumanHuman Frizzled-4 / FZD4 Protein, Fc Tag

Frizzled-4 / FZD4 Molecule Background

Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD4 contains one FZ (frizzled) domain. FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD4 interacts with MAGI3 and norrin (NDP).

Reference

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