IL12a / NKSF1 Molecule
IL-12A / NKSF1 Molecule Synonym Name
IL-12A / NKSF1 Protein Products
|Cat No||Species||Product Description|
|NK1-H5252||Human||Human IL-12A / NKSF1 / p35 Protein, Fc Tag|
IL-12A / NKSF1 Molecule Background
Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. Interleukin-12 subunit alpha (IL12A) also known as NKSF1, CLMF1 and P35, IL12A shows significant sequence similarity to IL-6, G-CSF, and exerts biological activities only when the IL12B is co-expressed. IL12B deficient mice are resistant to the induction of experimental chronic inflammatory diseases whereas IL12A knock-out mice develop more severe forms, suggesting opposite functions of the two subunits in the outcome of chronic inflammatory diseases.
- (1) Kaliński P, et al., 1997, J. Immunol. 159 (1): 28–35.
- (2) Chehimi J, et al., 1993, Eur J Immunol., 23(8):1826-30.
- (3) Thierfelder WE, et al., Nature., 382(6587):171-4.