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Browse By Molecule Name --->PCSK9 / NARC1 Molecule

PCSK9 / NARC1 Molecule  


PCSK9 Molecule Synonym Name

PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9

PCSK9 Protein Products

Cat No Species Product Description
PC9-C5223CynomolgusCynomolgus PCSK9 Protein
PC9-C52H2Rhesus macaqueRhesus macaque PCSK9 Protein
PC9-H5223HumanHuman PCSK9 Protein
PC9-H5226HumanHuman Mature PCSK9 (153-692) Protein
PC9-H528cHumanHuman PCSK9 Protein, Strep Tag
PC9-H52E4HamsterHamster PCSK9 Protein
PC9-H82E7HumanBiotinylated Human PCSK9, Avi Tag (Avitag?)
PC9-H9223HumanHuman PCSK9 Protein, C13 and N15-labeled
PC9-M5228MouseMouse PCSK9 Protein
PC9-M82E1MouseBiotinylated Mouse PCSK9, Avi Tag (Avitag?)
PC9-M9228MouseC13 and N15-labeled, Mouse PCSK9 Protein
PC9-R52H4RatRat PCSK9 Protein
PCA-H5226HumanHuman PCSK9 (R194A) Protein
PCY-H5225HumanHuman PCSK9 (D374Y) Protein
PCY-H82E7HumanBiotinylated Human PCSK9 (D374Y), Avi Tag (Avitag?)

PCSK9 Molecule Background

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Reference

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