PCSK9 / NARC1 Molecule
PCSK9 Molecule Synonym Name
PCSK9 Protein Products
|Cat No||Species||Product Description|
|PC9-C5223||Cynomolgus||Cynomolgus PCSK9 Protein|
|PC9-C52H2||Rhesus macaque||Rhesus macaque PCSK9 Protein|
|PC9-H5223||Human||Human PCSK9 Protein|
|PC9-H5226||Human||Human Mature PCSK9 (153-692) Protein|
|PC9-H528c||Human||Human PCSK9 Protein, Strep Tag|
|PC9-H52E4||Hamster||Hamster PCSK9 Protein|
|PC9-H82E7||Human||Biotinylated Human PCSK9, Avi Tag (Avitag?)|
|PC9-H9223||Human||Human PCSK9 Protein, C13 and N15-labeled|
|PC9-M5228||Mouse||Mouse PCSK9 Protein|
|PC9-M82E1||Mouse||Biotinylated Mouse PCSK9, Avi Tag (Avitag?)|
|PC9-M9228||Mouse||C13 and N15-labeled, Mouse PCSK9 Protein|
|PC9-R52H4||Rat||Rat PCSK9 Protein|
|PCA-H5226||Human||Human PCSK9 (R194A) Protein|
|PCY-H5225||Human||Human PCSK9 (D374Y) Protein|
|PCY-H82E7||Human||Biotinylated Human PCSK9 (D374Y), Avi Tag (Avitag?)|
PCSK9 Molecule Background
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
- (1) Seidah NG, et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 100 (3): 928–33.
- (2) Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
- (3) Dubuc G. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (8): 1454–9.