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Human TGF-beta RII / TGFBR2 Protein, Fc Tag  pdf  pdf  pdf


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TG2-H5252-100ug
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Synonym

TGFBR2, TGFR2, TbetaR-II, TGFβR2

Source

Recombinant Human TGFBR2 /TGFR2 Protein, with C-Fc Tag (rh TGFBR2 / TGFR2 Fc Chimera) Thr 23 - Asp 159 (Accession # NP_003233) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

rh TGFBR2 / TGFR2 Fc Chimera is fused with human IgG1 Fc tag at the C-terminus, and has a calculated MW of 42 kDa. The predicted N-terminus is Thr 23. DTT-reduced Protein migrates as 55-66 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the rh TGFBR2 / TGFR2 Fc Chimera by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human TGFBR2 /TGFR2 Protein, with C-Fc Tag
The purity of rh TGFBR2 / TGFR2 Fc Chimera was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Citations

Background

TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

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References

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