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Human Complement Factor D / CFD Protein  pdf  pdf  pdf


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CFD-H5227-50ug
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Synonym

CFD,Adipsin,PFD,DF,Complement factor D

Source

Human Complement Factor D / CFD Protein (Human Complement Factor D, His Tag) Ile 26 - Ala 253 (Accession # AAH57807) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

Human Complement Factor D, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 25.2 kDa. The predicted N-terminus is Ile 26. The reducing (R) protein migrates as 27 kDa in SDS-PAGE .

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM NaCl, pH 7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).

 

SDS-PAGE


Human Complement Factor D / CFD Protein
Human Complement Factor D, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
 
 

Background

Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.

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References

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