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Human Complement Factor D / CFD Protein  pdf  pdf  pdf


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CFD-H5227-50ug
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CFD-H5227-1mg (250ug x 4)
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Synonym

CFD,Adipsin,PFD,DF,Complement factor D

Source

Human Complement Factor D, His Tag (CFD-H5227) is expressed from human 293 cells (HEK293). It contains AA Ile 26 - Ala 253 (Accession # AAH57807).

Predicted N-terminus: Ile 26

Molecular Characterization

CFD(Ile 26 - Ala 253)AAH57807
Poly-his

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 25.2 kDa. The protein migrates as 27 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human Complement Factor D, His Tag (Cat. No. CFD-H5227) SDS-PAGE gel

Human Complement Factor D, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

 

Background

Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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