CFD,Adipsin,PFD,DF,Complement factor D
Human Complement Factor D / CFD Protein (Human Complement Factor D, His Tag) Ile 26 - Ala 253 (Accession # AAH57807) was produced in human 293 cells (HEK293) at ACROBiosystems.
Human Complement Factor D, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 25.2 kDa. The predicted N-terminus is Ile 26. The reducing (R) protein migrates as 27 kDa in SDS-PAGE .
Less than 1.0 EU per μg by the LAL method.
>90% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM NaCl, pH 7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
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See Certificate of Analysis for reconstitution instructions and specific concentrations.
Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).
Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.
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