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Human MAD2L1 Protein  pdf  pdf  pdf


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Synonym

MAD2L1,MAD2,HsMAD2

Source

Human MAD2L1, His Tag (MA1-H5123) is expressed from E.coli cells. It contains AA Met 1 - Asp 205 (Accession # NP_002349).

Predicted N-terminus: Met 1

Molecular Characterization

MAD2L1(Met 1 - Asp 205)NP_002349
Poly-his

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 24.3 kDa. The protein migrates as 24 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human MAD2L1, His Tag (Cat. No. MA1-H5123) SDS-PAGE gel

Human MAD2L1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

Background

Mitotic arrest deficient 2-like protein 1 (MAD2L1) is also known as Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2), MAD2. MAD2L1 / MAD2 belongs to the MAD2 family. MAD2L1 / MAD2 contains one HORMA domain. MAD2L1 is the component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 / MAD2 is required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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