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Human Lumican Protein  pdf  pdf  pdf


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Synonym

LUM, Lumican, LDC, SLRR2D, KSPG lumican

Source

Recombinant Human Lumican /LUM Protein (rh Lumican /LUM) Gln 19 - Asn 338 (Accession # NP_002336) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

rh Lumican /LUM is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 37.5 kDa. The predicted N-terminus is Gln 19. DTT-reduced Protein migrates as 50-65 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the rh Lumican /LUM by the LAL method.

Purity

>95% as determined by reduced SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human Lumican /LUM Protein
The purity of rh Lumican /LUM was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Lumican (LUM) is also known as Keratan sulfate proteoglycan lumican, KSPG lumican,LDC and SLRR2D, which belongs to the small leucine-rich proteoglycan (SLRP) family and SLRP class II subfamily. LUM /Lumican is present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage LUM /Lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan. LUM participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of LUM has been correlated to the growth and metastasis of various malignancies.

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References

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