Recombinant Human Serum Albumin /HSA Protein (Recombinant HSA) Asp 25 - Leu 609 (Accession # NP_000468) was produced in human 293 cells (HEK293) at ACROBiosystems.
Recombinant HSA is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 67.3 kDa. The predicted N-terminus is Asp 25. DTT-reduced Protein migrates as 66 kDa in SDS-PAGE due to glycosylation.
Less than 1.0 EU per μg of the Recombinant HSA by the LAL method.
>95% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
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See Certificate of Analysis for reconstitution instructions and specific concentrations.
Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Human serum albumin (HSA) is also known as ALB,which is the main protein of plasma and has a good binding capacity for water,Ca2+,Na+,K+,fatty acids,hormones, bilirubin and drugs.The main function of HSA is the regulation of the colloidal osmotic pressure of blood. As Major zinc transporter in plasma, HSA typically binds about 80% of all plasma zinc.A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. Defects in serum albumin can cause familial dysalbuminemic hyperthyroxinemia which is a form of euthyroid hyperthyroxinemia that is due to increased affinity of serum albumin for T4.It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.
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