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Human TDGF1 / Cripto Protein, Fc Tag  pdf  pdf  pdf


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Synonym

TDGF1, CRGF, CRIPTO

Source

Recombinant Human Cripto /TDGF1 Protein,C-Fc Tag,HEK293 expressed (rh Cripto /TDGF1 Fc Chimera) Leu 31 - Thr 172 (Accession # NP_003203) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

rh Cripto /TDGF1 Fc Chimera is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 42.6 kDa. The predicted N-terminus is Leu 31. The reducing (R) protein migrates as 44-55 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the rh Cripto /TDGF1 Fc Chimera by the LAL method.

Purity

>92% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human Cripto /TDGF1 Protein,C-Fc Tag,HEK293 expressed
The purity of rh Cripto /TDGF1 Fc Chimera was determined by SDS-PAGE under reducing (R) condition and staining overnight with Coomassie Blue.
 
 

Background

Teratocarcinoma-derived growth factor 1 (TDGF1) is also known as Cripto-1 growth factor (CRGF), Epidermal growth factor-like cripto protein CR1, CRIPTO, is a cell membrane which contains one EGF-like domain. TDGF1 is preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. TDGF1 interacts with the activin type-1 receptor ACVR1B. TDGF1 could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

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References

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