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Human VAP-B Protein  pdf  pdf  pdf


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Synonym

VAPB,ALS8,VAMP-B

Source

Human VAP-B, His Tag (VAB-H5127) is expressed from E.coli cells. It contains AA Met 1 - Pro 132 (Accession # NP_004729).

Predicted N-terminus: Met 1

Molecular Characterization

VAP-B(Met 1 - Pro 132)NP_004729
Poly-his

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 15.8 kDa. The protein migrates as 16-18 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human VAP-B, His Tag (Cat. No. VAB-H5127) SDS-PAGE gel

Human VAP-B, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

Background

Vesicle-associated membrane protein-associated protein B/C (VAPB) is also known as VAMP-associated protein B/C (VAMP-B/VAMP-C or VAP-B/VAP-C), which is a single-pass type IV membrane protein and belongs to the VAMP-associated protein ( VAP ) family. Involved in cellular calcium homeostasis regulation, VAPB participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity as well. VAPB can interact with VAMP1 ,VAMP2, HCV NS5A, NS5B ,ZFYVE27 (via MSP domain) and RMDN3. Human VAPB is involved in hepatitis C virus replication through interaction with NS5A and NS5B.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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