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Your Position: Home > Cytokines & Growth Factors > Human IL-12B & IL-12A Protein, His Tag & Flag Tag

Human IL-12B & IL-12A Heterodimer Protein, His Tag & Flag Tag

  • Synonym
  • Source
    Recombinant Human IL-12B & IL-12A heterodimer protein (Human IL-12B & IL-12A heterodimer) Ile 23 - Ser 328 (IL-12B, AAH67499) and Arg 23 - Ser 219 (IL-12A, P29459) was produced in human 293 cells (HEK293) at ACROBiosystems.
    Predicted N-terminus: Ile 23 (IL12B) and Arg 23 (IL12A)
  • Molecular Characterization
    IL-12B & IL-12A(Ile 23 - Ser 328 (IL-12B) and Arg 23 - Ser 219 (IL-12A)) AAH67499 (IL12B) and  P29459 (IL12A)

    The heterodimer Human IL-12B & IL-12A is produced by co-expression of IL-12B and IL-12A, has a calculated MW of 36.6 kDa (IL-12B) and 23.8 kDa (IL-12A). Subunit IL-12B is fused with his tag at the C-terminus and subunit IL-12A is fused with flag tag at the C-terminus. The predicted N-terminus is Ile 23 (IL12B) and Arg 23 (IL12A). The reducing (R) heterodimer protein migrates as 33-47 kDa due to glyosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Human IL-12B & IL-12A, His Tag & Flag Tag (Cat. No. IL2-H4210) SDS-PAGE gel

Human IL-12B & IL-12A, His Tag & Flag Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.
  • References
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